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GO:0005085: guanyl-nucleotide exchange factor activity (Molecular function)

"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]


There are 1395 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_536 Brassica rapa 33.33 % 0.002125 0.012752
Cluster_157 Brassica rapa 2.05 % 1.1e-05 0.000441
Cluster_270 Lactuca sativa 25.0 % 0.00267 0.011349
Cluster_110 Spinacia oleracea 3.77 % 0.000235 0.003831
Cluster_122 Spinacia oleracea 1.15 % 0.000176 0.001068
Sequences (1395) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms