GO:0017183: protein histidyl modification to diphthamide (Biological process)

"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380]


There are 59 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_151 Brassica rapa 1.18 % 0.004152 0.016733
Cluster_108 Spinacia oleracea 1.69 % 0.001692 0.016994
Sequences (59) (download table)

InterPro Domains

GO Terms

Family Terms